Drug interactions
Dronedarone + Voxelotor
Severity: Moderate
Dronedarone and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may raise concentrations of sensitive substrates like dronedarone. Higher dronedarone levels increase the risk of QT prolongation and bradycardia.
What this interaction means in plain words
Dronedarone and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Voxelotor belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 reduces dronedarone metabolism.
What to do
Avoid if possible; otherwise monitor ECG and heart rate and consider a lower dronedarone exposure strategy or an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Dronedarone with Voxelotor?
MediHelp rates the interaction as moderate. Dronedarone and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and may raise concentrations of sensitive substrates like dronedarone. Higher dronedarone levels increase the risk of QT prolongation and bradycardia.
How serious is the interaction between Dronedarone and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor ECG and heart rate and consider a lower dronedarone exposure strategy or an alternative.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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