Drug interactions
Dronedarone + Warfarin
Severity: Major
Dronedarone and Warfarin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone co-administration with warfarin has been associated with a raised INR and bleeding events. The effect can be variable and may appear after treatment starts.
What this interaction means in plain words
Dronedarone and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
Why it happens
The mechanism is not firmly established; possible contributions include altered warfarin metabolism and additive effects on hemostasis.
What to do
Check INR closely after starting or stopping dronedarone, for example weekly at first, and adjust the warfarin dose. Counsel the patient on bleeding signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Dronedarone with Warfarin?
MediHelp rates the interaction as major. Dronedarone and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone co-administration with warfarin has been associated with a raised INR and bleeding events. The effect can be variable and may appear after treatment starts.
How serious is the interaction between Dronedarone and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR closely after starting or stopping dronedarone, for example weekly at first, and adjust the warfarin dose. Counsel the patient on bleeding signs.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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