Drug interactions
Dronedarone + Zafirlukast
Severity: Moderate
Dronedarone and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast is reported to inhibit CYP3A4 in vitro, which could increase dronedarone exposure and QT prolongation or other adverse effects. Clinical evidence of a meaningful effect is limited.
What this interaction means in plain words
Dronedarone and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Zafirlukast belongs to Respiratory.
Why it happens
Possible CYP3A4 inhibition by zafirlukast reducing dronedarone metabolism; clinical significance is unproven.
What to do
Monitor ECG (QT interval), heart rate and dronedarone adverse effects if combined. Consider an alternative asthma agent if QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Zafirlukast?
MediHelp rates the interaction as moderate. Dronedarone and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zafirlukast is reported to inhibit CYP3A4 in vitro, which could increase dronedarone exposure and QT prolongation or other adverse effects. Clinical evidence of a meaningful effect is limited.
How serious is the interaction between Dronedarone and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG (QT interval), heart rate and dronedarone adverse effects if combined. Consider an alternative asthma agent if QT prolongation develops.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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