Drug interactions
Droperidol + Lisdexamfetamine
Severity: Moderate
Droperidol and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol prolongs the QT interval and causes sedation, while lisdexamfetamine is a stimulant that can cause tachycardia and arrhythmias. The stimulant may mask sedation, and the cardiac risks may be additive. Droperidol also antagonises dopaminergic effects.
What this interaction means in plain words
Droperidol and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS effects plus potential additive proarrhythmic effects; droperidol blocks dopamine receptors and prolongs QT.
What to do
Obtain an ECG and correct potassium and magnesium before droperidol use in patients on lisdexamfetamine. Monitor rhythm and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Droperidol with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Droperidol and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droperidol prolongs the QT interval and causes sedation, while lisdexamfetamine is a stimulant that can cause tachycardia and arrhythmias. The stimulant may mask sedation, and the cardiac risks may be additive. Droperidol also antagonises dopaminergic effects.
How serious is the interaction between Droperidol and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct potassium and magnesium before droperidol use in patients on lisdexamfetamine. Monitor rhythm and sedation.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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