Drug interactions
Droperidol + Posaconazole
Severity: Major
Droperidol and Posaconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and droperidol carries a boxed warning for torsades de pointes. Combined use increases the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Droperidol and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation through hERG channel blockade.
What to do
Avoid the combination, using a different antiemetic such as one without QT effects. If it cannot be avoided, obtain an ECG and correct electrolytes beforehand, with continuous ECG monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Droperidol with Posaconazole?
MediHelp rates the interaction as major. Droperidol and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and droperidol carries a boxed warning for torsades de pointes. Combined use increases the risk of serious ventricular arrhythmia.
How serious is the interaction between Droperidol and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, using a different antiemetic such as one without QT effects. If it cannot be avoided, obtain an ECG and correct electrolytes beforehand, with continuous ECG monitoring.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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