Drug interactions
Droperidol + Prochlorperazine
Severity: Major
Droperidol and Prochlorperazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are dopamine antagonists that prolong the QT interval, and droperidol carries a boxed warning for torsades de pointes. Combined use raises arrhythmia risk, and extrapyramidal effects and sedation also add up.
What this interaction means in plain words
Droperidol and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation and dopamine D2 antagonism.
What to do
Avoid concurrent use and choose a different antiemetic class. If unavoidable, obtain a baseline ECG, monitor continuously and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Droperidol with Prochlorperazine?
MediHelp rates the interaction as major. Droperidol and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are dopamine antagonists that prolong the QT interval, and droperidol carries a boxed warning for torsades de pointes. Combined use raises arrhythmia risk, and extrapyramidal effects and sedation also add up.
How serious is the interaction between Droperidol and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a different antiemetic class. If unavoidable, obtain a baseline ECG, monitor continuously and correct electrolytes.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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