Drug interactions
Drospirenone + Hydrochlorothiazide-irbesartan
Severity: Moderate
Drospirenone and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and, with an angiotensin receptor blocker, may raise serum potassium. Hydrochlorothiazide lowers potassium and may partially counteract this.
What this interaction means in plain words
Drospirenone and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Drospirenone antagonizes mineralocorticoid receptors while irbesartan reduces aldosterone effect, both decreasing renal potassium excretion.
What to do
Check serum potassium during the first cycle of combined use. Consider a different contraceptive if hyperkalemia or renal impairment is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Drospirenone and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and, with an angiotensin receptor blocker, may raise serum potassium. Hydrochlorothiazide lowers potassium and may partially counteract this.
How serious is the interaction between Drospirenone and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of combined use. Consider a different contraceptive if hyperkalemia or renal impairment is present.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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