Drug interactions
Drospirenone + Hydrochlorothiazide
Severity: Moderate
Drospirenone and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise potassium, partly offsetting thiazide-induced potassium loss. The net effect is variable, and hyperkalemia is possible in patients with renal or adrenal impairment.
What this interaction means in plain words
Drospirenone and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Opposing effects on potassium: drospirenone antagonizes aldosterone while hydrochlorothiazide increases renal potassium loss.
What to do
Check serum potassium in the first cycle of combined use in at-risk patients. Avoid drospirenone in renal impairment or adrenal insufficiency.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Drospirenone and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise potassium, partly offsetting thiazide-induced potassium loss. The net effect is variable, and hyperkalemia is possible in patients with renal or adrenal impairment.
How serious is the interaction between Drospirenone and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in the first cycle of combined use in at-risk patients. Avoid drospirenone in renal impairment or adrenal insufficiency.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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