Drug interactions
Drospirenone + Idelalisib
Severity: Moderate
Drospirenone and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and drospirenone is partly metabolized by CYP3A4, so drospirenone exposure may rise. The legacy direction is reversed: drospirenone is not a meaningful CYP3A4 inhibitor, so idelalisib levels are not expected to change.
What this interaction means in plain words
Drospirenone and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Idelalisib belongs to Oncology.
Why it happens
Idelalisib inhibits CYP3A4, which may reduce drospirenone clearance and raise its levels and potassium-related effects.
What to do
Monitor serum potassium in patients with renal impairment or on other potassium-raising drugs during co-administration. Consider the clinical context and an alternative contraceptive if hyperkalemia risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Drospirenone with Idelalisib?
MediHelp rates the interaction as moderate. Drospirenone and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A4 inhibitor and drospirenone is partly metabolized by CYP3A4, so drospirenone exposure may rise. The legacy direction is reversed: drospirenone is not a meaningful CYP3A4 inhibitor, so idelalisib levels are not expected to change.
How serious is the interaction between Drospirenone and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with renal impairment or on other potassium-raising drugs during co-administration. Consider the clinical context and an alternative contraceptive if hyperkalemia risk factors are present.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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