Drug interactions
Drospirenone + Lopinavir
Severity: Moderate
Drospirenone and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir inhibits CYP3A4 and may raise drospirenone exposure, although ritonavir may also induce other pathways that reduce hormonal contraceptive efficacy. Drospirenone does not meaningfully raise lopinavir levels.
What this interaction means in plain words
Drospirenone and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted lopinavir alters CYP3A4-mediated and other metabolism of drospirenone.
What to do
Monitor serum potassium and consider an additional or alternative contraceptive method.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Drospirenone with Lopinavir?
MediHelp rates the interaction as moderate. Drospirenone and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir inhibits CYP3A4 and may raise drospirenone exposure, although ritonavir may also induce other pathways that reduce hormonal contraceptive efficacy. Drospirenone does not meaningfully raise lopinavir levels.
How serious is the interaction between Drospirenone and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and consider an additional or alternative contraceptive method.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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