Drug interactions
Drospirenone + Metolazone
Severity: Moderate
Drospirenone and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise potassium, while metolazone lowers it. The net effect varies between patients, and hyperkalaemia is a concern if renal function is reduced.
What this interaction means in plain words
Drospirenone and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Metolazone belongs to Cardiovascular.
Why it happens
Opposing pharmacodynamic effects: drospirenone antagonises aldosterone and retains potassium, whereas metolazone promotes renal potassium loss.
What to do
Check serum potassium during the first cycle of combined use and periodically thereafter, particularly in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Metolazone?
MediHelp rates the interaction as moderate. Drospirenone and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise potassium, while metolazone lowers it. The net effect varies between patients, and hyperkalaemia is a concern if renal function is reduced.
How serious is the interaction between Drospirenone and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of combined use and periodically thereafter, particularly in patients with renal impairment.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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