Drug interactions
Drospirenone + Nevirapine
Severity: Moderate
Drospirenone and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine is expected to lower drospirenone exposure, which may reduce contraceptive reliability. Drospirenone does not meaningfully raise nevirapine concentrations. The clinically important direction is reduced hormone effect.
What this interaction means in plain words
Drospirenone and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, increasing metabolism of drospirenone and co-administered estrogen.
What to do
Advise an additional or alternative non-hormonal contraceptive method, or use an intrauterine or injectable option. Do not rely on oral hormonal contraception alone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Nevirapine?
MediHelp rates the interaction as moderate. Drospirenone and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine is expected to lower drospirenone exposure, which may reduce contraceptive reliability. Drospirenone does not meaningfully raise nevirapine concentrations. The clinically important direction is reduced hormone effect.
How serious is the interaction between Drospirenone and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional or alternative non-hormonal contraceptive method, or use an intrauterine or injectable option. Do not rely on oral hormonal contraception alone.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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