Drug interactions
Drospirenone + Omaveloxolone
Severity: Moderate
Drospirenone and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is a weak CYP3A4 inducer and may reduce drospirenone exposure, potentially lowering contraceptive efficacy.
What this interaction means in plain words
Drospirenone and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Omaveloxolone belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by omaveloxolone may increase drospirenone metabolism.
What to do
Add a non-hormonal barrier method during treatment or choose a non-hormonal contraceptive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Drospirenone with Omaveloxolone?
MediHelp rates the interaction as moderate. Drospirenone and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone is a weak CYP3A4 inducer and may reduce drospirenone exposure, potentially lowering contraceptive efficacy.
How serious is the interaction between Drospirenone and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a non-hormonal barrier method during treatment or choose a non-hormonal contraceptive.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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