Drug interactions
Drospirenone + Ranolazine
Severity: Minor
Drospirenone and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has little meaningful CYP3A4 inhibitory activity at clinical doses, so a relevant increase in ranolazine exposure is unlikely. No clinically important interaction is expected.
What this interaction means in plain words
Drospirenone and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Ranolazine belongs to Cardiovascular.
Why it happens
Theoretical weak CYP3A4 inhibition by drospirenone; not established clinically.
What to do
No action is generally needed. Monitor for usual ranolazine adverse effects such as dizziness and constipation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Ranolazine?
MediHelp rates the interaction as minor. Drospirenone and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has little meaningful CYP3A4 inhibitory activity at clinical doses, so a relevant increase in ranolazine exposure is unlikely. No clinically important interaction is expected.
How serious is the interaction between Drospirenone and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed. Monitor for usual ranolazine adverse effects such as dizziness and constipation.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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