Drug interactions
Drospirenone + Siltuximab
Severity: Minor
Drospirenone and Siltuximab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siltuximab blocks IL-6 and can restore suppressed CYP450 activity, potentially lowering concentrations of CYP substrates. Drospirenone is a minor CYP3A4 substrate, so any effect is probably small.
What this interaction means in plain words
Drospirenone and Siltuximab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Siltuximab belongs to Miscellaneous.
Why it happens
IL-6 inhibition reverses cytokine-mediated downregulation of CYP3A4, increasing drospirenone metabolism.
What to do
No routine adjustment; monitor contraceptive effectiveness and bleeding patterns in the weeks after starting or stopping siltuximab.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Drospirenone
Other interactions of Siltuximab
- Baricitinib + Siltuximab Major
- Atorvastatin + Siltuximab Moderate
- Carbamazepine + Siltuximab Moderate
- Cyclosporin + Siltuximab Moderate
- Ethinyl estradiol-drospirenone + Siltuximab Moderate
- Ethinyl estradiol-levonorgestrel + Siltuximab Moderate
Frequently asked questions
Can I take Drospirenone with Siltuximab?
MediHelp rates the interaction as minor. Drospirenone and Siltuximab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Siltuximab blocks IL-6 and can restore suppressed CYP450 activity, potentially lowering concentrations of CYP substrates. Drospirenone is a minor CYP3A4 substrate, so any effect is probably small.
How serious is the interaction between Drospirenone and Siltuximab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor contraceptive effectiveness and bleeding patterns in the weeks after starting or stopping siltuximab.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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