Drug interactions
Drospirenone + Sotalol
Severity: Minor
Drospirenone and Sotalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone can raise serum potassium through anti-mineralocorticoid action. Hyperkalemia is clinically relevant to sotalol users because electrolyte disturbances alter QT and arrhythmia risk, though the risk from drospirenone alone is modest.
What this interaction means in plain words
Drospirenone and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Sotalol belongs to Cardiovascular.
Why it happens
Drospirenone's anti-mineralocorticoid effect and beta-blocker impairment of cellular potassium uptake may additively raise potassium.
What to do
Check serum potassium at baseline and periodically, particularly with renal impairment or other potassium-raising drugs. Correct electrolyte abnormalities.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Sotalol?
MediHelp rates the interaction as minor. Drospirenone and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone can raise serum potassium through anti-mineralocorticoid action. Hyperkalemia is clinically relevant to sotalol users because electrolyte disturbances alter QT and arrhythmia risk, though the risk from drospirenone alone is modest.
How serious is the interaction between Drospirenone and Sotalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium at baseline and periodically, particularly with renal impairment or other potassium-raising drugs. Correct electrolyte abnormalities.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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