Drug interactions
Dulaglutide + Insulin glargine
Severity: Moderate
Dulaglutide and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide added to basal insulin lowers glucose further and increases hypoglycemia risk. Insulin dose reduction is often needed.
What this interaction means in plain words
Dulaglutide and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Insulin glargine belongs to Endocrine.
Why it happens
Additive glucose lowering from exogenous insulin and GLP-1 receptor agonism with glucose-dependent insulin secretion and glucagon suppression.
What to do
Monitor glucose when starting dulaglutide and consider lowering the insulin dose to prevent hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Dulaglutide
Frequently asked questions
Can I take Dulaglutide with Insulin glargine?
MediHelp rates the interaction as moderate. Dulaglutide and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dulaglutide added to basal insulin lowers glucose further and increases hypoglycemia risk. Insulin dose reduction is often needed.
How serious is the interaction between Dulaglutide and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting dulaglutide and consider lowering the insulin dose to prevent hypoglycemia.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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