Drug interactions
Dulaglutide + Saxagliptin
Severity: Moderate
Dulaglutide and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide and saxagliptin both enhance incretin signaling, so combining them adds little glycemic benefit. Hypoglycemia is unlikely unless insulin or a sulfonylurea is also used.
What this interaction means in plain words
Dulaglutide and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Saxagliptin belongs to Endocrine.
Why it happens
Overlapping incretin effects: GLP-1 receptor activation plus DPP-4 inhibition that raises endogenous GLP-1.
What to do
Generally avoid the combination because of limited added efficacy. If used, monitor glucose and reduce any concurrent insulin or sulfonylurea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dulaglutide
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Dulaglutide with Saxagliptin?
MediHelp rates the interaction as moderate. Dulaglutide and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dulaglutide and saxagliptin both enhance incretin signaling, so combining them adds little glycemic benefit. Hypoglycemia is unlikely unless insulin or a sulfonylurea is also used.
How serious is the interaction between Dulaglutide and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Generally avoid the combination because of limited added efficacy. If used, monitor glucose and reduce any concurrent insulin or sulfonylurea.
What other medicines interact with Dulaglutide?
MediHelp also lists interactions of Dulaglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Dulaglutide page.
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