Drug interactions
Dulaglutide + Sirolimus
Severity: Minor
Dulaglutide and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide slows gastric emptying and could alter the rate of sirolimus absorption. Sirolimus has a narrow therapeutic index, so changes in exposure could matter, although a clinically significant effect has not been well documented.
What this interaction means in plain words
Dulaglutide and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dulaglutide belongs to Endocrine; Sirolimus belongs to Miscellaneous.
Why it happens
Delayed gastric emptying from GLP-1 receptor activation may alter oral absorption of sirolimus.
What to do
Check sirolimus trough concentrations after starting or changing the dulaglutide dose. Adjust the sirolimus dose according to levels.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dulaglutide and Sirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dulaglutide
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Dulaglutide with Sirolimus?
MediHelp rates the interaction as minor. Dulaglutide and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dulaglutide slows gastric emptying and could alter the rate of sirolimus absorption. Sirolimus has a narrow therapeutic index, so changes in exposure could matter, although a clinically significant effect has not been well documented.
How serious is the interaction between Dulaglutide and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sirolimus trough concentrations after starting or changing the dulaglutide dose. Adjust the sirolimus dose according to levels.
What other medicines interact with Dulaglutide?
MediHelp also lists interactions of Dulaglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Dulaglutide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
