Drug interactions
Duloxetine + Fesoterodine
Severity: Minor
Duloxetine and Fesoterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine is a moderate CYP2D6 inhibitor and may raise exposure to the active metabolite of fesoterodine. The increase is expected to be modest and mainly relevant for antimuscarinic adverse effects.
What this interaction means in plain words
Duloxetine and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duloxetine belongs to Central Nervous System; Fesoterodine belongs to Genitourinary.
Why it happens
Duloxetine inhibits CYP2D6, which contributes to clearance of the active metabolite of fesoterodine.
What to do
No dose adjustment is usually needed; monitor for dry mouth, constipation and urinary retention.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Fesoterodine?
MediHelp rates the interaction as minor. Duloxetine and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duloxetine is a moderate CYP2D6 inhibitor and may raise exposure to the active metabolite of fesoterodine. The increase is expected to be modest and mainly relevant for antimuscarinic adverse effects.
How serious is the interaction between Duloxetine and Fesoterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for dry mouth, constipation and urinary retention.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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