Drug interactions
Duloxetine + Frovatriptan
Severity: Moderate
Duloxetine and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a serotonin-norepinephrine reuptake inhibitor with a triptan may raise serotonergic activity and, rarely, cause serotonin syndrome with agitation, tremor, hyperthermia and autonomic instability. The absolute risk is low and the combination is often used in practice.
What this interaction means in plain words
Duloxetine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Frovatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from reuptake inhibition (duloxetine) and 5-HT1B/1D agonism (frovatriptan).
What to do
Counsel the patient on early symptoms of serotonin syndrome and review the need for both drugs. Stop both agents and treat supportively if neuromuscular, autonomic or mental status changes appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Duloxetine with Frovatriptan?
MediHelp rates the interaction as moderate. Duloxetine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a serotonin-norepinephrine reuptake inhibitor with a triptan may raise serotonergic activity and, rarely, cause serotonin syndrome with agitation, tremor, hyperthermia and autonomic instability. The absolute risk is low and the combination is often used in practice.
How serious is the interaction between Duloxetine and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on early symptoms of serotonin syndrome and review the need for both drugs. Stop both agents and treat supportively if neuromuscular, autonomic or mental status changes appear.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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