Drug interactions
Duloxetine + Ganaxolone
Severity: Moderate
Duloxetine and Ganaxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a neuroactive steroid GABA-A modulator that causes somnolence and sedation. Combined with duloxetine, which can cause drowsiness and dizziness, CNS depression and impaired alertness may be greater.
What this interaction means in plain words
Duloxetine and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Ganaxolone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excessive sedation and falls, and advise patients to avoid driving or hazardous tasks until response is known. Reduce the dose of ganaxolone or duloxetine if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Duloxetine with Ganaxolone?
MediHelp rates the interaction as moderate. Duloxetine and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a neuroactive steroid GABA-A modulator that causes somnolence and sedation. Combined with duloxetine, which can cause drowsiness and dizziness, CNS depression and impaired alertness may be greater.
How serious is the interaction between Duloxetine and Ganaxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and falls, and advise patients to avoid driving or hazardous tasks until response is known. Reduce the dose of ganaxolone or duloxetine if sedation is troublesome.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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