Drug interactions
Duloxetine + Ibrutinib
Severity: Moderate
Duloxetine and Ibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib inhibits platelet function and is associated with bleeding, including serious hemorrhage. Duloxetine also impairs platelet serotonin uptake, so the two together may further increase bleeding risk.
What this interaction means in plain words
Duloxetine and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Ibrutinib belongs to Oncology.
Why it happens
Additive impairment of platelet aggregation and hemostasis through BTK inhibition and SNRI-induced platelet serotonin depletion.
What to do
Monitor for bruising, gastrointestinal and other bleeding, and review other agents affecting hemostasis. Consider an alternative antidepressant in patients with a high bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Duloxetine with Ibrutinib?
MediHelp rates the interaction as moderate. Duloxetine and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib inhibits platelet function and is associated with bleeding, including serious hemorrhage. Duloxetine also impairs platelet serotonin uptake, so the two together may further increase bleeding risk.
How serious is the interaction between Duloxetine and Ibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising, gastrointestinal and other bleeding, and review other agents affecting hemostasis. Consider an alternative antidepressant in patients with a high bleeding risk.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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