Drug interactions
Duloxetine + Nilotinib
Severity: Moderate
Duloxetine and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib can inhibit CYP2D6 and may modestly raise duloxetine exposure. Both drugs can also cause QT-related or cardiovascular effects, although duloxetine has a low QT liability.
What this interaction means in plain words
Duloxetine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP2D6 metabolism of duloxetine; additive QT effects are possible but weak.
What to do
Monitor for duloxetine adverse effects and consider ECG monitoring, as recommended for nilotinib, with correction of potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Duloxetine with Nilotinib?
MediHelp rates the interaction as moderate. Duloxetine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib can inhibit CYP2D6 and may modestly raise duloxetine exposure. Both drugs can also cause QT-related or cardiovascular effects, although duloxetine has a low QT liability.
How serious is the interaction between Duloxetine and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects and consider ECG monitoring, as recommended for nilotinib, with correction of potassium and magnesium.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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