Drug interactions
Duloxetine + Propranolol
Severity: Moderate
Duloxetine and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine is a moderate CYP2D6 inhibitor and can increase propranolol exposure. This may cause greater bradycardia and hypotension.
What this interaction means in plain words
Duloxetine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Propranolol belongs to Cardiovascular.
Why it happens
Duloxetine inhibits CYP2D6, reducing propranolol clearance.
What to do
Monitor heart rate and blood pressure after starting or changing the duloxetine dose. Reduce the propranolol dose if symptomatic bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Propranolol?
MediHelp rates the interaction as moderate. Duloxetine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine is a moderate CYP2D6 inhibitor and can increase propranolol exposure. This may cause greater bradycardia and hypotension.
How serious is the interaction between Duloxetine and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting or changing the duloxetine dose. Reduce the propranolol dose if symptomatic bradycardia or hypotension develops.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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