Drug interactions
Duloxetine + Pseudoephedrine
Severity: Moderate
Duloxetine and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine inhibits norepinephrine reuptake and may amplify the pressor and chronotropic effects of pseudoephedrine. This can raise blood pressure and heart rate, mainly in patients with cardiovascular disease.
What this interaction means in plain words
Duloxetine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Pseudoephedrine belongs to Respiratory.
Why it happens
Additive noradrenergic pharmacodynamic effects from reuptake inhibition and sympathomimetic action.
What to do
Monitor blood pressure and heart rate when combining, and avoid in uncontrolled hypertension. Prefer non-sympathomimetic decongestants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Pseudoephedrine?
MediHelp rates the interaction as moderate. Duloxetine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine inhibits norepinephrine reuptake and may amplify the pressor and chronotropic effects of pseudoephedrine. This can raise blood pressure and heart rate, mainly in patients with cardiovascular disease.
How serious is the interaction between Duloxetine and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when combining, and avoid in uncontrolled hypertension. Prefer non-sympathomimetic decongestants.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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