Drug interactions
Duloxetine + Tolmetin
Severity: Moderate
Duloxetine and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine inhibits serotonin reuptake and, combined with an NSAID, increases the risk of upper gastrointestinal bleeding. The risk is higher in older patients and those with prior GI bleeding.
What this interaction means in plain words
Duloxetine and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Tolmetin belongs to Musculoskeletal.
Why it happens
Duloxetine impairs platelet serotonin uptake and aggregation, adding to NSAID COX-1 inhibition and mucosal injury.
What to do
Use the lowest effective NSAID dose for the shortest time and consider a proton pump inhibitor in high-risk patients. Monitor for signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Tolmetin?
MediHelp rates the interaction as moderate. Duloxetine and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine inhibits serotonin reuptake and, combined with an NSAID, increases the risk of upper gastrointestinal bleeding. The risk is higher in older patients and those with prior GI bleeding.
How serious is the interaction between Duloxetine and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and consider a proton pump inhibitor in high-risk patients. Monitor for signs of GI bleeding.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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