Drug interactions
Duloxetine + Tolterodine
Severity: Minor
Duloxetine and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine is a moderate CYP2D6 inhibitor and can raise tolterodine exposure. Tolterodine is also cleared via CYP3A4, and its active metabolite maintains overall antimuscarinic activity, so the net effect is usually modest. Anticholinergic adverse effects may be somewhat more frequent.
What this interaction means in plain words
Duloxetine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duloxetine belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Inhibition of CYP2D6-mediated conversion of tolterodine to its 5-hydroxymethyl metabolite, raising parent drug levels.
What to do
No routine dose change is needed; monitor for dry mouth, constipation and urinary retention. Consider a lower tolterodine dose if anticholinergic effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Tolterodine?
MediHelp rates the interaction as minor. Duloxetine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duloxetine is a moderate CYP2D6 inhibitor and can raise tolterodine exposure. Tolterodine is also cleared via CYP3A4, and its active metabolite maintains overall antimuscarinic activity, so the net effect is usually modest. Anticholinergic adverse effects may be somewhat more frequent.
How serious is the interaction between Duloxetine and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for dry mouth, constipation and urinary retention. Consider a lower tolterodine dose if anticholinergic effects emerge.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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