Drug interactions
Duloxetine + Zuranolone
Severity: Moderate
Duloxetine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone is a neuroactive steroid GABA-A modulator that causes somnolence and impaired driving ability, and antidepressants such as duloxetine can add to CNS effects. Zuranolone is itself used alongside antidepressants for postpartum depression, so the combination is manageable.
What this interaction means in plain words
Duloxetine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects from GABA-A modulation and duloxetine.
What to do
Counsel patients not to drive or operate machinery for at least 12 hours after zuranolone dosing. Reduce the zuranolone dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Duloxetine with Zuranolone?
MediHelp rates the interaction as moderate. Duloxetine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone is a neuroactive steroid GABA-A modulator that causes somnolence and impaired driving ability, and antidepressants such as duloxetine can add to CNS effects. Zuranolone is itself used alongside antidepressants for postpartum depression, so the combination is manageable.
How serious is the interaction between Duloxetine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients not to drive or operate machinery for at least 12 hours after zuranolone dosing. Reduce the zuranolone dose if excessive sedation occurs.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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