Drug interactions
Dupilumab + Primidone
Severity: Minor
Dupilumab and Primidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dupilumab may restore CYP activity suppressed by chronic inflammation, potentially altering the metabolism of primidone and its active metabolites. Because of its narrow therapeutic range, changes could affect seizure control. The effect is theoretical.
What this interaction means in plain words
Dupilumab and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dupilumab belongs to Respiratory; Primidone belongs to Central Nervous System.
Why it happens
Normalization of cytokine-suppressed CYP450 expression after IL-4 receptor blockade, potentially altering primidone metabolism.
What to do
Monitor seizure control and primidone/phenobarbital levels when dupilumab is started or stopped. Adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dupilumab
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Dupilumab with Primidone?
MediHelp rates the interaction as minor. Dupilumab and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dupilumab may restore CYP activity suppressed by chronic inflammation, potentially altering the metabolism of primidone and its active metabolites. Because of its narrow therapeutic range, changes could affect seizure control. The effect is theoretical.
How serious is the interaction between Dupilumab and Primidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and primidone/phenobarbital levels when dupilumab is started or stopped. Adjust the dose if needed.
What other medicines interact with Dupilumab?
MediHelp also lists interactions of Dupilumab with, for example, Smallpox vaccine live, Adenovirus types 4 and 7 live, Bcg vaccine live. The full list is on the Dupilumab page.
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