Drug interactions
Dutasteride + Erythromycin stearate
Severity: Minor
Dutasteride and Erythromycin stearate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4, which metabolizes dutasteride, so dutasteride levels may increase. Dutasteride has a very long half-life and wide margin, so short courses are unlikely to matter.
What this interaction means in plain words
Dutasteride and Erythromycin stearate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Erythromycin inhibits CYP3A4 metabolism of dutasteride.
What to do
No adjustment is generally needed; monitor for dutasteride adverse effects if erythromycin is used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
Frequently asked questions
Can I take Dutasteride with Erythromycin stearate?
MediHelp rates the interaction as minor. Dutasteride and Erythromycin stearate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits CYP3A4, which metabolizes dutasteride, so dutasteride levels may increase. Dutasteride has a very long half-life and wide margin, so short courses are unlikely to matter.
How serious is the interaction between Dutasteride and Erythromycin stearate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is generally needed; monitor for dutasteride adverse effects if erythromycin is used long term.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Dutasteride page.
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