Drug interactions
Dutasteride + Indinavir
Severity: Minor
Dutasteride and Indinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may increase dutasteride concentrations. The effect is usually of limited clinical importance given dutasteride's tolerability.
What this interaction means in plain words
Dutasteride and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated dutasteride metabolism by indinavir.
What to do
No routine dose adjustment is needed. Monitor for dutasteride adverse effects during long-term co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
Frequently asked questions
Can I take Dutasteride with Indinavir?
MediHelp rates the interaction as minor. Dutasteride and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir inhibits CYP3A4 and may increase dutasteride concentrations. The effect is usually of limited clinical importance given dutasteride's tolerability.
How serious is the interaction between Dutasteride and Indinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Monitor for dutasteride adverse effects during long-term co-therapy.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Dutasteride page.
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