Drug interactions
Dutasteride + Isoniazid
Severity: Minor
Dutasteride and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has weak, inconsistent CYP3A4 inhibitory activity and might slightly raise dutasteride levels in theory. No clinically meaningful effect has been established.
What this interaction means in plain words
Dutasteride and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dutasteride belongs to Genitourinary; Isoniazid belongs to Anti Bacterial.
Why it happens
Possible weak CYP3A4 inhibition by isoniazid reducing dutasteride metabolism.
What to do
No action is generally required beyond routine monitoring of dutasteride adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
Other interactions of Isoniazid
Frequently asked questions
Can I take Dutasteride with Isoniazid?
MediHelp rates the interaction as minor. Dutasteride and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid has weak, inconsistent CYP3A4 inhibitory activity and might slightly raise dutasteride levels in theory. No clinically meaningful effect has been established.
How serious is the interaction between Dutasteride and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required beyond routine monitoring of dutasteride adverse effects.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Dutasteride page.
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