Drug interactions
Dutasteride + Marijuana
Severity: Minor
Dutasteride and Marijuana: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids can inhibit CYP3A4 in vitro, but clinical effects on dutasteride exposure are not demonstrated. Any interaction is theoretical.
What this interaction means in plain words
Dutasteride and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible in vitro CYP3A4 inhibition by cannabinoids; clinical relevance not established.
What to do
No dose adjustment is required. Counsel the patient to report new adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
Frequently asked questions
Can I take Dutasteride with Marijuana?
MediHelp rates the interaction as minor. Dutasteride and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabinoids can inhibit CYP3A4 in vitro, but clinical effects on dutasteride exposure are not demonstrated. Any interaction is theoretical.
How serious is the interaction between Dutasteride and Marijuana?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Counsel the patient to report new adverse effects.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Dutasteride page.
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