Drug interactions
Dutasteride + Topiramate
Severity: Minor
Dutasteride and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate is a weak CYP3A4 inducer at higher doses and might slightly lower dutasteride levels. A meaningful clinical effect is unlikely.
What this interaction means in plain words
Dutasteride and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dutasteride belongs to Genitourinary; Topiramate belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by topiramate may increase dutasteride metabolism.
What to do
No action is usually needed; reassess response if symptoms fail to improve.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
Other interactions of Topiramate
Frequently asked questions
Can I take Dutasteride with Topiramate?
MediHelp rates the interaction as minor. Dutasteride and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Topiramate is a weak CYP3A4 inducer at higher doses and might slightly lower dutasteride levels. A meaningful clinical effect is unlikely.
How serious is the interaction between Dutasteride and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed; reassess response if symptoms fail to improve.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Dutasteride page.
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