Drug interactions
Dutasteride-tamsulosin + Eliglustat
Severity: Moderate
Dutasteride-tamsulosin and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits CYP2D6 and can increase tamsulosin exposure, as tamsulosin is partly metabolized by CYP2D6 and CYP3A4. This may increase dizziness and orthostatic hypotension, particularly in CYP2D6 poor metabolizers or those on other inhibitors.
What this interaction means in plain words
Dutasteride-tamsulosin and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Eliglustat belongs to Miscellaneous.
Why it happens
Inhibition of CYP2D6 by eliglustat reduces tamsulosin clearance.
What to do
Monitor blood pressure and orthostatic symptoms. Consider reducing the tamsulosin dose or choosing an alternative if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Eliglustat?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits CYP2D6 and can increase tamsulosin exposure, as tamsulosin is partly metabolized by CYP2D6 and CYP3A4. This may increase dizziness and orthostatic hypotension, particularly in CYP2D6 poor metabolizers or those on other inhibitors.
How serious is the interaction between Dutasteride-tamsulosin and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms. Consider reducing the tamsulosin dose or choosing an alternative if adverse effects develop.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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