Drug interactions
Dutasteride-tamsulosin + Fosaprepitant
Severity: Minor
Dutasteride-tamsulosin and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, a prodrug of aprepitant, is a moderate CYP3A4 inhibitor. A single dose may transiently raise tamsulosin and dutasteride concentrations. Clinically significant effects are uncommon but may include dizziness or low blood pressure.
What this interaction means in plain words
Dutasteride-tamsulosin and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dutasteride-tamsulosin belongs to Genitourinary; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant, the active form, inhibits CYP3A4 and modestly reduces the clearance of CYP3A4 substrates.
What to do
No routine adjustment is needed for a single dose. Counsel the patient to rise slowly and monitor for orthostatic symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Dutasteride-tamsulosin with Fosaprepitant?
MediHelp rates the interaction as minor. Dutasteride-tamsulosin and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, a prodrug of aprepitant, is a moderate CYP3A4 inhibitor. A single dose may transiently raise tamsulosin and dutasteride concentrations. Clinically significant effects are uncommon but may include dizziness or low blood pressure.
How serious is the interaction between Dutasteride-tamsulosin and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed for a single dose. Counsel the patient to rise slowly and monitor for orthostatic symptoms.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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