Drug interactions
Dutasteride-tamsulosin + Haloperidol
Severity: Moderate
Dutasteride-tamsulosin and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is a CYP2D6 inhibitor and a weak CYP3A4 inhibitor with some alpha-1 blocking activity. It may slightly raise tamsulosin exposure and add to orthostatic hypotension.
What this interaction means in plain words
Dutasteride-tamsulosin and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Haloperidol belongs to Central Nervous System.
Why it happens
Haloperidol inhibits CYP2D6 and CYP3A4 weakly and adds alpha-1 adrenergic blockade.
What to do
Monitor for orthostatic hypotension and dizziness, particularly in older adults. Adjust the tamsulosin dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Haloperidol?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol is a CYP2D6 inhibitor and a weak CYP3A4 inhibitor with some alpha-1 blocking activity. It may slightly raise tamsulosin exposure and add to orthostatic hypotension.
How serious is the interaction between Dutasteride-tamsulosin and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension and dizziness, particularly in older adults. Adjust the tamsulosin dose if symptoms occur.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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