Drug interactions
Dutasteride-tamsulosin + Iloperidone
Severity: Moderate
Dutasteride-tamsulosin and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has weak time-dependent CYP3A inhibitory activity and may raise tamsulosin exposure. Both drugs lower blood pressure through alpha-1 blockade, so additive orthostatic hypotension is a more relevant concern than the kinetic effect.
What this interaction means in plain words
Dutasteride-tamsulosin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Iloperidone belongs to Central Nervous System.
Why it happens
Additive alpha-1 adrenergic blockade, plus mild CYP3A inhibition that decreases tamsulosin clearance.
What to do
Monitor blood pressure and orthostatic symptoms, particularly during iloperidone titration. Reduce the dose of either agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Dutasteride-tamsulosin with Iloperidone?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone has weak time-dependent CYP3A inhibitory activity and may raise tamsulosin exposure. Both drugs lower blood pressure through alpha-1 blockade, so additive orthostatic hypotension is a more relevant concern than the kinetic effect.
How serious is the interaction between Dutasteride-tamsulosin and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly during iloperidone titration. Reduce the dose of either agent if symptomatic hypotension occurs.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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