Drug interactions
Dutasteride-tamsulosin + Letermovir
Severity: Moderate
Dutasteride-tamsulosin and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and may raise exposure to dutasteride and tamsulosin, both CYP3A substrates. Increased tamsulosin exposure may cause dizziness and hypotension. Dutasteride adverse effects are generally dose-tolerant.
What this interaction means in plain words
Dutasteride-tamsulosin and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP3A4, reducing the metabolic clearance of tamsulosin and dutasteride.
What to do
Monitor blood pressure and orthostatic symptoms during letermovir therapy. Reduce the tamsulosin dose or stop it if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Dutasteride-tamsulosin with Letermovir?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir is a moderate CYP3A inhibitor and may raise exposure to dutasteride and tamsulosin, both CYP3A substrates. Increased tamsulosin exposure may cause dizziness and hypotension. Dutasteride adverse effects are generally dose-tolerant.
How serious is the interaction between Dutasteride-tamsulosin and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms during letermovir therapy. Reduce the tamsulosin dose or stop it if hypotension develops.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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