Drug interactions
Dutasteride-tamsulosin + Ribociclib
Severity: Moderate
Dutasteride-tamsulosin and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may raise exposure to both tamsulosin and dutasteride. Higher tamsulosin levels can cause hypotension and dizziness.
What this interaction means in plain words
Dutasteride-tamsulosin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Ribociclib belongs to Oncology.
Why it happens
CYP3A4 inhibition reduces clearance of tamsulosin and dutasteride.
What to do
Monitor for orthostatic hypotension and dizziness during ribociclib treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Ribociclib?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may raise exposure to both tamsulosin and dutasteride. Higher tamsulosin levels can cause hypotension and dizziness.
How serious is the interaction between Dutasteride-tamsulosin and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension and dizziness during ribociclib treatment.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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