Drug interactions
Dutasteride-tamsulosin + Tipranavir
Severity: Major
Dutasteride-tamsulosin and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, is a strong CYP3A4 inhibitor and can markedly raise tamsulosin exposure. This may cause excessive alpha-blockade with hypotension, dizziness and syncope.
What this interaction means in plain words
Dutasteride-tamsulosin and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dutasteride-tamsulosin belongs to Genitourinary; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of tamsulosin (and dutasteride) reduces clearance and raises plasma concentrations.
What to do
Avoid the combination where possible and consider another BPH regimen or antiretroviral. If it is unavoidable, monitor blood pressure and orthostatic symptoms closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Tipranavir?
MediHelp rates the interaction as major. Dutasteride-tamsulosin and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir, given with ritonavir, is a strong CYP3A4 inhibitor and can markedly raise tamsulosin exposure. This may cause excessive alpha-blockade with hypotension, dizziness and syncope.
How serious is the interaction between Dutasteride-tamsulosin and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider another BPH regimen or antiretroviral. If it is unavoidable, monitor blood pressure and orthostatic symptoms closely.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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