Drug interactions
Dutasteride-tamsulosin + Voriconazole
Severity: Major
Dutasteride-tamsulosin and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole is a strong CYP3A4 inhibitor and can increase tamsulosin and dutasteride exposure. This raises the risk of hypotension, dizziness and syncope.
What this interaction means in plain words
Dutasteride-tamsulosin and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dutasteride-tamsulosin belongs to Genitourinary; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces clearance of tamsulosin and dutasteride.
What to do
Avoid concurrent use where possible, or withhold tamsulosin during voriconazole therapy. If both are used, monitor blood pressure and orthostatic symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Voriconazole?
MediHelp rates the interaction as major. Dutasteride-tamsulosin and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole is a strong CYP3A4 inhibitor and can increase tamsulosin and dutasteride exposure. This raises the risk of hypotension, dizziness and syncope.
How serious is the interaction between Dutasteride-tamsulosin and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, or withhold tamsulosin during voriconazole therapy. If both are used, monitor blood pressure and orthostatic symptoms.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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