Drug interactions
Duvelisib + Flibanserin
Severity: Major
Duvelisib and Flibanserin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates such as flibanserin. Higher flibanserin levels increase the risk of hypotension, syncope and sedation.
What this interaction means in plain words
Duvelisib and Flibanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duvelisib belongs to Oncology; Flibanserin belongs to Genitourinary.
Why it happens
Duvelisib inhibits CYP3A4-mediated metabolism of flibanserin, increasing its systemic exposure.
What to do
Avoid the combination where possible, since flibanserin labeling cautions against moderate to strong CYP3A4 inhibitors. If unavoidable, monitor closely for hypotension, syncope and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Flibanserin?
MediHelp rates the interaction as major. Duvelisib and Flibanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates such as flibanserin. Higher flibanserin levels increase the risk of hypotension, syncope and sedation.
How serious is the interaction between Duvelisib and Flibanserin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, since flibanserin labeling cautions against moderate to strong CYP3A4 inhibitors. If unavoidable, monitor closely for hypotension, syncope and sedation.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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