Drug interactions
Duvelisib + Haloperidol
Severity: Moderate
Duvelisib and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can increase exposure to haloperidol, which is partly metabolized by this enzyme. Higher haloperidol levels raise the risk of QT prolongation, sedation and extrapyramidal symptoms.
What this interaction means in plain words
Duvelisib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Haloperidol belongs to Central Nervous System.
Why it happens
Duvelisib inhibition of CYP3A4 reduces haloperidol metabolism.
What to do
Consider reducing the haloperidol dose and monitor for extrapyramidal symptoms, sedation and QTc prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Haloperidol?
MediHelp rates the interaction as moderate. Duvelisib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and can increase exposure to haloperidol, which is partly metabolized by this enzyme. Higher haloperidol levels raise the risk of QT prolongation, sedation and extrapyramidal symptoms.
How serious is the interaction between Duvelisib and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the haloperidol dose and monitor for extrapyramidal symptoms, sedation and QTc prolongation.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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