Drug interactions
Duvelisib + Lurasidone
Severity: Major
Duvelisib and Lurasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib increases exposure to sensitive CYP3A4 substrates, so lurasidone levels may rise and cause more adverse effects. Concomitant use with strong CYP3A4 inhibitors is contraindicated for lurasidone, and duvelisib's effect is more modest.
What this interaction means in plain words
Duvelisib and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duvelisib belongs to Oncology; Lurasidone belongs to Central Nervous System.
Why it happens
Duvelisib inhibits CYP3A4, reducing lurasidone clearance.
What to do
Consider a lurasidone dose reduction (start 20 mg, maximum 80 mg daily) and monitor for akathisia, sedation and extrapyramidal effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Lurasidone?
MediHelp rates the interaction as major. Duvelisib and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib increases exposure to sensitive CYP3A4 substrates, so lurasidone levels may rise and cause more adverse effects. Concomitant use with strong CYP3A4 inhibitors is contraindicated for lurasidone, and duvelisib's effect is more modest.
How serious is the interaction between Duvelisib and Lurasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lurasidone dose reduction (start 20 mg, maximum 80 mg daily) and monitor for akathisia, sedation and extrapyramidal effects.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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