Drug interactions
Duvelisib + Ribociclib
Severity: Major
Duvelisib and Ribociclib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CYP3A substrates and inhibitors. Duvelisib is a CYP3A4 inhibitor that may increase ribociclib exposure and QT and neutropenia risk, and ribociclib may raise duvelisib levels, increasing its toxicities such as infection, diarrhea and skin reactions.
What this interaction means in plain words
Duvelisib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duvelisib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Mutual CYP3A4 inhibition raises exposure of both drugs.
What to do
Consider reducing the ribociclib dose, and reduce duvelisib if toxicity appears. Monitor ECG, electrolytes, blood counts and infection signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Ribociclib?
MediHelp rates the interaction as major. Duvelisib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are CYP3A substrates and inhibitors. Duvelisib is a CYP3A4 inhibitor that may increase ribociclib exposure and QT and neutropenia risk, and ribociclib may raise duvelisib levels, increasing its toxicities such as infection, diarrhea and skin reactions.
How serious is the interaction between Duvelisib and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the ribociclib dose, and reduce duvelisib if toxicity appears. Monitor ECG, electrolytes, blood counts and infection signs.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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