Drug interactions
Duvelisib + Saxagliptin
Severity: Moderate
Duvelisib and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and may increase saxagliptin exposure, raising the risk of dose-related adverse effects.
What this interaction means in plain words
Duvelisib and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Saxagliptin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 metabolism of saxagliptin.
What to do
Consider limiting saxagliptin to 2.5 mg daily and monitor for adverse effects and glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Saxagliptin?
MediHelp rates the interaction as moderate. Duvelisib and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and may increase saxagliptin exposure, raising the risk of dose-related adverse effects.
How serious is the interaction between Duvelisib and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider limiting saxagliptin to 2.5 mg daily and monitor for adverse effects and glucose.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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