Drug interactions
Duvelisib + Simvastatin
Severity: Major
Duvelisib and Simvastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib increases exposure to sensitive CYP3A4 substrates such as simvastatin, raising the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Duvelisib and Simvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duvelisib belongs to Oncology; Simvastatin belongs to Cardiovascular.
Why it happens
Duvelisib inhibits CYP3A4, decreasing simvastatin first-pass metabolism.
What to do
Avoid simvastatin during duvelisib therapy where possible, using a statin less reliant on CYP3A4 such as pravastatin or rosuvastatin. If continued, use a reduced dose and monitor for muscle symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
- Darunavir + Simvastatin Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Simvastatin?
MediHelp rates the interaction as major. Duvelisib and Simvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib increases exposure to sensitive CYP3A4 substrates such as simvastatin, raising the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Duvelisib and Simvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid simvastatin during duvelisib therapy where possible, using a statin less reliant on CYP3A4 such as pravastatin or rosuvastatin. If continued, use a reduced dose and monitor for muscle symptoms.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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