Drug interactions
Duvelisib + Sirolimus
Severity: Moderate
Duvelisib and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a CYP3A4 inhibitor and can increase exposure to sirolimus, a sensitive CYP3A4 substrate. Higher sirolimus levels raise the risk of immunosuppression-related infections, cytopenias and metabolic adverse effects.
What this interaction means in plain words
Duvelisib and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Duvelisib inhibits CYP3A4-mediated metabolism of sirolimus.
What to do
Monitor sirolimus trough concentrations and consider reducing the sirolimus dose during duvelisib therapy. Watch for signs of infection and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Duvelisib and Sirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Sirolimus?
MediHelp rates the interaction as moderate. Duvelisib and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is a CYP3A4 inhibitor and can increase exposure to sirolimus, a sensitive CYP3A4 substrate. Higher sirolimus levels raise the risk of immunosuppression-related infections, cytopenias and metabolic adverse effects.
How serious is the interaction between Duvelisib and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations and consider reducing the sirolimus dose during duvelisib therapy. Watch for signs of infection and toxicity.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
